Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure.
نویسندگان
چکیده
A novel bridged nucleic acid bearing cyclic urea structure was successfully synthesized and introduced into oligonucleotide, displaying attractive characteristics of highly RNA selective hybridization ability and excellent resistance towards nuclease degradation.
منابع مشابه
Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structurew
Since the Human Genome Project was completed, much attention has been given to genome technologies to regulate target gene expression or function. The most simple and promising approach to down-regulate target gene expression in a living cell is antisense strategy, which prevents translation by hybridization of an oligonucleotide with its complementary RNA strand. For practical use in antisense...
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 29 شماره
صفحات -
تاریخ انتشار 2010